High-Throughput screening system

1.1.

Buyer

Official name : Danmarks Tekniske Universitet - DTU

Email : mardau@dtu.dk

Legal type of the buyer : Body governed by public law

Activity of the contracting authority : Education

2.1.

Procedure

Title : High-Throughput screening system

Description : Due to a change in requirements for different types of analyses at DTU Biosustain, DTU intends to purchase a mass spectrometer that comprises all three following features: ion mobility, commercial DESI and possibility to implement commercial MALDI.

Procedure identifier : 72fa44ab-1637-41cf-82ce-713896490fde

Previous notice : f93a9b70-2f33-48f1-8745-0bbf939d5544-01

Internal identifier : 8980

Type of procedure : Negotiated without prior call for competition

2.1.1.

Purpose

Main nature of the contract : Supplies

Main classification ( cpv ): 38000000 Laboratory, optical and precision equipments (excl. glasses)

2.1.2.

Place of performance

Town : Kgs. Lyngby

Postcode : 2800

Country subdivision (NUTS) : Københavns omegn ( DK012 )

Country : Denmark

Additional information : Currently, the analytics department consists of equipment, which covers non-targeted and targeted metabolomics utilizing four different liquid chromatography-mass spectrometry (LC-MS) equipment. While these platforms can deliver data with high accuracy and sensitivity, they require extensive (and time consuming) sample preparation up front and none of the systems are able to perform high-throughput imaging analyses or ion mo-bility separations. Additionally, one of the above-mentioned equipment, which is currently used for targeted metabolomics, has come to the end of its lifetime (> 10 years old) and will have to be shut down in the near future due to malfunctions. Recently, there has been a change in requirements for different types of analyses at DTU Biosustain. There is now a need for more high-throughput anal-yses, which require minimal amount of sample preparation, as well as for separation of structural isomers of different metabolites and for imaging analyses of solid samples without extensive sample preparation. Given the current limitations in the existing equipment park, the analytics de-partment at DTU Biosustain is now looking into the possibility to purchase two new analytical sys-tems from Waters A/S. These systems should be suitable for high-throughput screening and imag-ing (simultaneously) as well as for high sensitivity, targeted metabolomics analyses utilizing either imaging or liquid chromatographic separation. Based on the changed needs of DTU Biosustain, the equipment wished to be purchased consists of the following: 1) Accurate mass MS system (SYNAPT XS) including ion mobility and a desorption elec-trospray ionization (DESI) source for high-throughput screening of samples as well as for imaging of liquid and solid samples. On this equipment, both the high-throughput screen-ing as well as the imaging can be done without extensive sample preparation and the data can be processed with the software provided with the equipment. In addition, the ion mobil-ity provides a possibility to separate isomers (which is currently not possible in the analyt-ics department laboratory at DTU Biosustain), and the equipment can also be updated for matrix assisted desorption/ionization (MALDI) imaging without the need to purchase a complete separate equipment setup for this. 2) High sensitivity liquid chromatography triple quadrupole MS system (UPLC-Xevo TQ Abso-lute) to be able to perform targeted measurements of low concentrations in biological samples. This system is supporting the possibility to connect the DESI-source to accurate-ly quantify identified compounds from the screening process mentioned in point 1 above. In addition, this equipment will provide DTU Biosustain with the additional throughput needed to supply the center with the data requested within the required timeframes.

2.1.4.

General information

Call for competition is terminated

Legal basis :

Directive 2014/24/EU

5.1.

Lot : LOT-0000

Title : High-Throughput screening system

Description : Due to a change in requirements for different types of analyses at DTU Biosustain, DTU intends to purchase a mass spectrometer that comprises all three following features: ion mobility, commercial DESI and possibility to implement commercial MALDI.

Internal identifier : 8980

5.1.1.

Purpose

Main nature of the contract : Supplies

Main classification ( cpv ): 38000000 Laboratory, optical and precision equipments (excl. glasses)

5.1.2.

Place of performance

Town : Kgs. Lyngby

Postcode : 2800

Country subdivision (NUTS) : Københavns omegn ( DK012 )

Country : Denmark

Additional information : Currently, the analytics department consists of equipment, which covers non-targeted and targeted metabolomics utilizing four different liquid chromatography-mass spectrometry (LC-MS) equipment. While these platforms can deliver data with high accuracy and sensitivity, they require extensive (and time consuming) sample preparation up front and none of the systems are able to perform high-throughput imaging analyses or ion mo-bility separations. Additionally, one of the above-mentioned equipment, which is currently used for targeted metabolomics, has come to the end of its lifetime (> 10 years old) and will have to be shut down in the near future due to malfunctions. Recently, there has been a change in requirements for different types of analyses at DTU Biosustain. There is now a need for more high-throughput anal-yses, which require minimal amount of sample preparation, as well as for separation of structural isomers of different metabolites and for imaging analyses of solid samples without extensive sample preparation. Given the current limitations in the existing equipment park, the analytics de-partment at DTU Biosustain is now looking into the possibility to purchase two new analytical sys-tems from Waters A/S. These systems should be suitable for high-throughput screening and imag-ing (simultaneously) as well as for high sensitivity, targeted metabolomics analyses utilizing either imaging or liquid chromatographic separation. Based on the changed needs of DTU Biosustain, the equipment wished to be purchased consists of the following: 1) Accurate mass MS system (SYNAPT XS) including ion mobility and a desorption elec-trospray ionization (DESI) source for high-throughput screening of samples as well as for imaging of liquid and solid samples. On this equipment, both the high-throughput screen-ing as well as the imaging can be done without extensive sample preparation and the data can be processed with the software provided with the equipment. In addition, the ion mobil-ity provides a possibility to separate isomers (which is currently not possible in the analyt-ics department laboratory at DTU Biosustain), and the equipment can also be updated for matrix assisted desorption/ionization (MALDI) imaging without the need to purchase a complete separate equipment setup for this. 2) High sensitivity liquid chromatography triple quadrupole MS system (UPLC-Xevo TQ Abso-lute) to be able to perform targeted measurements of low concentrations in biological samples. This system is supporting the possibility to connect the DESI-source to accurate-ly quantify identified compounds from the screening process mentioned in point 1 above. In addition, this equipment will provide DTU Biosustain with the additional throughput needed to supply the center with the data requested within the required timeframes.

5.1.6.

General information

Procurement Project not financed with EU Funds.

The procurement is covered by the Government Procurement Agreement (GPA) : yes

5.1.10.

Award criteria

Criterion :

Type : Price

Name : Price

Description : The price from the supplier is crucial.

Weight (percentage, exact) : 100

5.1.12.

Terms of procurement

Information about review deadlines : Complaint that the Contracting Authority, contrary to the Public Procurement Act, has concluded a contract without prior publication of a contract notice in the European Union Official Journal must be submitted no later than 30 calendar days from the date after a contract award notice has been published by the Contracting Authority in the European Union Official Journal and that contract award notice includes the grounds for the decision to award the contract directly, cf. lov om Klagenævnet for Udbud (Complaints Board for Tenders) § 7, section 3.

5.1.15.

Techniques

Framework agreement : No framework agreement

Information about the dynamic purchasing system : No dynamic purchase system

Electronic auction : no

5.1.16.

Further information, mediation and review

Review organisation : Klagenævnet for Udbud

Organisation providing information concerning the general regulatory framework for taxes applicable in the place where the contract is to be performed : Konkurrence- og Forbrugerstyrelsen

Organisation providing additional information about the procurement procedure : Danmarks Tekniske Universitet - DTU

Organisation providing offline access to the procurement documents : Danmarks Tekniske Universitet - DTU

Organisation whose budget is used to pay for the contract : Danmarks Tekniske Universitet - DTU

Organisation executing the payment : Danmarks Tekniske Universitet - DTU

Organisation signing the contract : Danmarks Tekniske Universitet - DTU

TED eSender : Mercell Holding ASA

Value of all contracts awarded in this notice : 7 017 931,80 DKK

Direct award :

Justification for direct award : The contract can be provided only by a particular economic operator because of an absence of competition for technical reasons

Other justification : Waters A/S (the Danish branch of WatersTM) is the only vendor, who can supply DTU Biosustain with a commercial DESI source. The DESI technology was first introduced in 2004 in the laboratory of Graham Cooks (Purdue University) in the USA. Since then, numerous laboratories have developed their own, in-house built, DESI sources worldwide. These sources have not been out on the market for users to purchase and thus, WatersTM acquired the rights to the DESITM IP from Prosolia Inc. and the Purdue Research Foundation in 2018. This makes WatersTM the exclusive provider of this technology and it also means that the commercial DESI source, by WatersTM, can only be connected to mass spectrometers by WatersTM. The SYNAPT XS is the only mass spectrometer on the market comprising all three following features: ion mobility, commercial DESI and possibility to implement commercial MALDI. The need for these features has been described above. Multiple other vendors can provide a high sensitivity LC-MS for targeted measurements of low concentrations in biological samples, but the system provided by Waters A/S (is the only system on the market, which can be used with the commercial DESI source (which is to be purchased with the SYNAPT XS mentioned above). The possibility to connect the DESI source to the high sensitivity LC-MS system is required for the analytics department at DTU Biosustain to accurately quantify the compounds identified during the screening step using the SYNAPT XS. It is also of great importance to be able to connect the LC-system with the SYNAPT XS and that all these units can be controlled by one software (provided by Waters A/S with the equipment). This is not possible if a system from another vendor is chosen since acquisition software are equipment dependent and license based. Therefore, the only possibility to successfully achieve the required analyses is to purchase this specific equipment from Waters A/S. Additionally, the energy and gas consumption of this equipment is one of the lowest on the market and therefore, it also produces less heat than most other comparable equipment. This is an important aspect from a sustainability perspective, but also from a laboratory infrastructure perspective. The analytics department laboratory at DTU Biosustain is currently limited in cooling capacity and thus a higher heat production will cause extensive cost additions due to major changes required in the laboratory infrastructure and due to additional energy consumption (even after the implemented changes in the infrastructure) to keep the laboratory at an acceptable temperature (i.e. below 25 °C). Other justification: There is lack of competition due to technical reasons, cf. § 80, subsection 3, no. 2 in the Danish Public Procurement Law. This technical capability is mandatory for the future work at DTU Biosustain as there are requests for such analyses. It is not possible to analyse solid samples providing imaging data using any other equipment available on the market. Furthermore, it is a major part of the future plans for DTU Biosustain beyond 2025 to analyse solid samles (solid food-related samples).

6.1.

Result lot ldentifier : LOT-0000

Winner selection status : At least one winner was chosen.

6.1.2.

Information about winners

Winner :

Official name : Waters A/S

Tender :

Tender identifier : 374008

Identifier of lot or group of lots : LOT-0000

Concession value:

Subcontracting : No

Contract information:

Identifier of the contract : 8980

Title : Contract regarding a mass spectrometry based equipment for high-throughput screening and imaging purposes.

Date on which the winner was chosen : 21/08/2024

Date of the conclusion of the contract : 17/09/2024

Organisation signing the contract : Danmarks Tekniske Universitet - DTU

6.1.4.

Statistical information :

Received tenders or requests to participate :

Type of received submissions : Tenders

Number of tenders or requests to participate received : 1

8.1.

ORG-0001

Official name : Danmarks Tekniske Universitet - DTU

Registration number : 30060946

Postal address : Anker Engelunds Vej 1

Town : Kgs. Lyngby

Postcode : 2800

Country subdivision (NUTS) : Københavns omegn ( DK012 )

Country : Denmark

Contact point : Marianne Dauding

Email : mardau@dtu.dk

Telephone : +45 33344398

Internet address : https://www.dtu.dk/

Buyer profile : https://eu.eu-supply.com/ctm/company/companyinformation/index/165863

Roles of this organisation :

Buyer

Organisation providing additional information about the procurement procedure

Organisation providing offline access to the procurement documents

Organisation signing the contract

Organisation whose budget is used to pay for the contract

Organisation executing the payment

8.1.

ORG-0002

Official name : Klagenævnet for Udbud

Registration number : 37795526

Postal address : Nævnenes hus, Toldboden 2

Town : Viborg

Postcode : 8800

Country subdivision (NUTS) : Østjylland ( DK042 )

Country : Denmark

Email : klfu@erst.dk

Telephone : +45 35291000

Internet address : http://www.kfst.dk/

Roles of this organisation :

Review organisation

8.1.

ORG-0003

Official name : Konkurrence- og Forbrugerstyrelsen

Registration number : 10294819

Postal address : Carl Jacobsens Vej 35

Town : Valby

Postcode : 2500

Country subdivision (NUTS) : Københavns omegn ( DK012 )

Country : Denmark

Email : kfst@kfst.dk

Telephone : +45 41715000

Internet address : http://www.kfst.dk

Roles of this organisation :

Organisation providing information concerning the general regulatory framework for taxes applicable in the place where the contract is to be performed

8.1.

ORG-0004

Official name : Waters A/S

Registration number : 17554034

Postal address : Dybendalsvænget 2

Town : Taastrup

Postcode : 2630

Country subdivision (NUTS) : Københavns omegn ( DK012 )

Country : Denmark

Email : denmark@waters.com

Telephone : +4546598080

Roles of this organisation :

Tenderer

Winner of these lots : LOT-0000

8.1.

ORG-0005

Official name : Mercell Holding ASA

Registration number : 980921565

Postal address : Askekroken 11

Town : Oslo

Postcode : 0277

Country subdivision (NUTS) : Oslo ( NO081 )

Country : Norway

Contact point : eSender

Email : publication@mercell.com

Telephone : +47 21018800

Fax : +47 21018801

Internet address : http://mercell.com/

Roles of this organisation :

TED eSender

11.1.

Notice information

Notice identifier/version : f3c79e2a-c7e9-48f0-85ed-7c75fe55ea84 - 01

Form type : Result

Notice type : Contract or concession award notice – standard regime

Notice subtype : 29

Notice dispatch date : 30/09/2024 11:34:03 (UTC)

Notice dispatch date (eSender) : 30/09/2024 12:00:43 (UTC)

Languages in which this notice is officially available : English

11.2.

Publication information

Notice publication number : 587992-2024

OJ S issue number : 191/2024

Publication date : 01/10/2024

Fakta om udbudet

High-Throughput screening system

Danmarks Tekniske Universitet - DTU