23948sdkhjf

Fakta om udbudet

EU-nr
2021/S 017-038979
Offentliggjort
26.01.2021
Udbudstype
Udbud med forhandling uden forudgående offentliggørelse

Udbyder

University of Copenhagen

Vindere

(26.01.2021)
Abberior Instruments GmbH
Hans-Adolf-Krebs-Weg 1
37077 Göttingen

Acquisition of a Infinity Line Confocal and 3D STED Super-resolution Microscope


University of Copenhagen

Voluntary ex ante transparency notice

Supplies

Legal Basis:
Directive 2014/24/EU

Section I: Contracting authority/entity

I.1) Name and addresses
Official name: University of Copenhagen
Postal address: Nørregade 10
Town: Copenhagen K
NUTS code: DK01 Hovedstaden
Postal code: 1165
Country: Denmark
Contact person: Mahmut Yüksel
E-mail: FGN253@ku.dk
Internet address(es):
Main address: www.KU.dk
I.4) Type of the contracting authority
Body governed by public law
I.5) Main activity
Education

Section II: Object

II.1) Scope of the procurement
II.1.1) Title:

Acquisition of a Infinity Line Confocal and 3D STED Super-resolution Microscope

II.1.2) Main CPV code
38510000 Microscopes
II.1.3) Type of contract
Supplies
II.1.4) Short description:

Lab of Alexander Matthias Walter, Department of Neuroscience, Faculty of Health and Medical Science, University of Copenhagen.

II.1.6) Information about lots
This contract is divided into lots: no
II.1.7) Total value of the procurement (excluding VAT)
Value excluding VAT: 550 000.00 EUR
II.2) Description
II.2.3) Place of performance
NUTS code: DK01 Hovedstaden
II.2.4) Description of the procurement:

The microscope shall be used as combined confocal/STED setup to investigate how scaffolding proteins and release factors allow efficient synaptic vesicle fusion at synaptic vesicle release sites. The sub-diffraction size of these release sites (< 70 nm) requires the highest possible resolution to investigate the molecular arrangement within these sites and how molecules ‘react’ when release sites alter their activity e.g. during learning.

II.2.5) Award criteria
II.2.11) Information about options
Options: no
II.2.13) Information about European Union funds
The procurement is related to a project and/or programme financed by European Union funds: no
II.2.14) Additional information

Section IV: Procedure

IV.1) Description
IV.1.1) Type of procedure
Negotiated procedure without prior publication
  • The works, supplies or services can be provided only by a particular economic operator for the following reason:
    • absence of competition for technical reasons
Explanation:

Our research focuses on the identification of neuronal mechanisms to achieve stable and dynamic function by plasticity modifications of the synaptic transmission strength. In the recent years we identified Unc13 as the protein that defines the position where a synaptic vesicles release their neurotransmitters that signal to neighboring cells. These release sites are positioned with nanometer precision with respect to the release inducing Ca2+ source and this is crucial for the efficacy of signal transmission and the processing of temporal information. We now identified mutations within the Unc13 gene which facilitate neurotransmitter release by altering the release probability of synaptic vesicles. One explanation for this would be a shift of Unc13 to smaller distances with respect to the Ca2+ source. Preliminary mathematical calculations suggest that distance shifts of 20 nm would be sufficient to induce such a change. Thus, to investigate whether the position of Unc13 changes with respect to the Ca2+ source upon release potentiation, a microscope is required that delivers a XY resolution of below 30 nm. The STED microscope by Abberior Instruments we want to purchase is currently is the only microscope that can achieve such a resolution.

We also need to investigate the nanoscale topology with respect to distances perpendicular to the plasma membrane (additional Z-axis). To investigate this possibility a microscope is required that allows STED imaging in 3D without a significant loss of resolution. Again, the STED microscope we want to purchase from Abberior Instruments is the only supplier of a specific technology package for super-resolution imaging in 2D as well as in 3D. This includes the easy3D STED technology, a unique proprietary technology (see patent below). Without the highest resolution or the easy3D the goal of our research project ‘The cooperative synapse’ funded by the Novo Nordisk Young Investigator award would not be achievable.

Finally, STED is a rather complicated technology. To achieve the highest possible resolution, the excitation and STED laser have to be properly aligned. Previous devices required manual alignment which is both time consuming and must be done by an expert (e.g. a specialised engineer). This support is not available at KU. Therefore, the only way to use the system at high performance is a software- and hardware based autoalignment. Abberior Instruments now provides such a solution which is absolutely unique (see patent below).

Abberior Instruments is currently the only supplier of a specific technology package including options like DyMIN STED, RESCue STED or MINFIELD STED. Those options are currently not part of our configuration, but will be purchased as future upgrade.

— German utility model DE 20 2015 105 046 (U1);

— German laid open patent application DE 10 2014 113 716 (A1);

— European laid open patent application EP 3 507 642 (A1) (To be granted 20 January 2021);

— Chinese laid open application CN 109923459 (A);

— US laid open patent application US 2019 195 800 (A1).

IV.1.3) Information about framework agreement
IV.1.8) Information about the Government Procurement Agreement (GPA)
The procurement is covered by the Government Procurement Agreement: yes
IV.2) Administrative information

Section V: Award of contract/concession

V.2) Award of contract/concession
V.2.1) Date of contract award decision:
27/12/2020
V.2.2) Information about tenders
The contract has been awarded to a group of economic operators: no
V.2.3) Name and address of the contractor/concessionaire
Official name: Abberior Instruments GmbH
Postal address: Hans-Adolf-Krebs-Weg 1
Town: Göttingen
NUTS code: DE DEUTSCHLAND
Postal code: 37077
Country: Germany
Telephone: +49 55130724170
Internet address: www.abberior-instruments.com
The contractor/concessionaire will be an SME: no
V.2.4) Information on value of the contract/lot/concession (excluding VAT)
Total value of the contract/lot/concession: 550 000.00 EUR
V.2.5) Information about subcontracting

Section VI: Complementary information

VI.3) Additional information:
VI.4) Procedures for review
VI.4.1) Review body
Official name: Danish Public Contracts Appeal Board
Postal address: Nævnenes hus, toldboden 2
Town: Viborg
Postal code: 8800
Country: Denmark
E-mail: NH@naevneneshus.dk
Telephone: +45 72405600
Internet address: www.KLFU.dk
VI.5) Date of dispatch of this notice:
21/01/2021

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