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Overordnet internetadresse: https://permalink.mercell.com/105771290.aspx

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Atomic Force Microscope for studying biomolecular interfaces.

Purchase of an Atomic Force Microscope (AFM) for research purposes at The University of Southern Denmark (SDU).

General description:

Atomic Force Microscope (AFM) for studying biomolecular interfaces. The instrument will be part of a project aimed at studying membrane-protein interactions in cells and artificial systems. A key aspect of the planned experiments is the best possible integration of AFM and optical microscopy.

The University of Southern Denmark (SDU)

— XYZ tip scanner to allow for simultaneous AFM and optical imaging. Reason: A tip-scanner design (i.e. non-moving sample) is required for simultaneous AFM and optical imaging which is essential for the planned experiments integrating the two techniques,

— The AFM allows the use of the inverted optical microscopes condenser optics to enable techniques such as phase imaging and differential interference contrast (relevant patents US 7022985, US 7473894, EP 1430485, JP 4044042) simultaneous to fast AFM with large range scanner of 100x100 in x and y of 70 Hz line rate at 2 um scan range. Reason: The combination of AFM and phase contrast/DIC is required for the planned work on cells under conditions where cells cannot be fluorescently labeled. Fast AFM scanning (min 70Hz) is generally requested for following dynamic processes in cells and model systems,

— The AFM allows the use of the inverted optical microscopes high NA fluorescence optics simultaneous to fast AFM with large range scanner of 100x100 in x and y of 70 Hz line rate at 2 um scan range. Reason: The use of high NA optics in required to achieve the maximum quality of fluorescence images in combination with AFM,

— AFM and optical microscopy imaging space correlation, DirectOverlay (Trade Mark Sign) patented in US 368017, JP 5172696, CN 101395676. Reason: A perfect automated alignment of AFM and optical images is essential for the project when identifying correlations between AFM and optical imaging results,

— data pixel information bandwidth in fast force mapping of 2 kHz with linear z motion providing raw force curve data allowing full force curve analysis, QI (Trade Mark Sign). Reason: Availability of the full force curve data is required for exploring membrane-protein interactions without limitations of a predefined analysis,

— Stepper motor z range can be integrated into force mapping allowing large range z mapping, e.g., for tissue engineering patented in US 8291511. Reason: Extension of the z-range by the stepper motors is required for force mapping (membrane-protein interactions) on cellular surface having large height variations,

— Atomic lattice resolution on optical microscope with fast AFM of more than 50 Hz line rate. Reason: Atomic resolution at high scan speeds (>50Hz) is required for single molecule resolution of protein overlayers on membranes under dynamic conditions,

— Tip holders made from glass and stainless steel to allow for cleaning by means of sonication or autoclaving must be available. Reason: Efficient cleaning and sterilization of the cantilever holder is necessary when working with potentially harmful substances or pathogenic systems in the project.

Public Procurement Act Section 80, litra 3 and 4 - Only one supplier:

The AFM system can only be supplied by one particular economic operator due to technical reasons. There is an objective and proportionate reason for the establishment of specifications which result in there being only one supplier.

The possibility that there are other potential suppliers who could deliver the same has been objectively excluded by market consultations.

Internetadresse: www.blue-scientific.com

Internetadresse: http://www.klfu.dk

Pursuant to the Danish Act on Complaints Board for Public Procurement (act no. 492 of 12.5.2010 with subsequent amendments - available at www.retsinformation.dk), the following time limits for filing a complaint apply: Complaints regarding a candidate not being pre-qualified must be filed with The Complaints Board for Public Procurement within 20 calendar days starting the day after the contracting authority has sent notification to the candidates involved, cf. § 171 (2) of the Danish Act on Public Procurement (act no. 1564 of 15.12.2015 - available at www.retsinformation.dk) of § 7 (1) of the Danish Act on The Complaints Board for Public Procurement, provided that the notification includes a short account of the relevant reasons for the decision. Other complaints must be filed with the Complaints Board for Public Procurement within:

1) 45 calendar days after the contracting authority has published a contract award notice in the Official Journal of the European Union (with effect from the day following the publication date);

2) 30 calendar days starting the day after the contracting authority has informed the tenderers in question, that the contracting authority has entered into a contract based on a framework agreement through reopening of competition or a dynamic purchasing system, provided that the notification includes a short account of the relevant reasons for the decision;

3) 6 months starting the day after the contracting authority has sent notification to the candidates/tenderers involved that the contracting authority has entered into the framework agreement, cf. § 2 (2) or § 171 (4) of the Act on Public Procurement, provided that the notification included a short account of the relevant reasons for the decision;

4) 20 calendar days starting the day after the contracting authority has published a notice concerning his decision to uphold the contract, cf. § 185 (2) of the Act on Public Procurement.

The complainant must inform the contracting authority of the complaint in writing at the latest simultaneously with the lodge of the complaint to The Complaints Board for Public Procurement stating whether the complaint has been lodged in the stand-still period, cf. § 6 (4) of the Act on The Complaints Board for Public Procurement. If the complaint has not been lodged in the stand-still period, the complainant must also state whether it is requested that the appeal is granted delaying effect, cf. § 12 (1) of the said Act. The email of the Complaints Board for Public Procurement is stated in section VI.4.1. The Complaints Board for Public Procurement's own guidance note concerning complaints is available at the internet address stated in section VI.4.1

Internetadresse: http://www.kfst.dk